BDBM50164787 CHEMBL3798088

SMILES CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C

InChI Key InChIKey=SILRGLDFBXVGOQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50164787   

TargetHistone-lysine N-methyltransferase 2A(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 320nMAssay Description:Inhibition of SUMO-His-tagged MLL1 activity (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using histone H3 as substrate by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2017
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of SUMO-His-tagged WDR5 (unknown origin) interaction with MLL1 assessed as displacement of fluorescence labelled Ac-ARA peptide substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2017
Entry Details Article
PubMed
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 300nMAssay Description:Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of fluorescence-labeled Ac-ARA peptide binding to WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant SUMO-tagged MLL1 (unknown origin) by histone methyl transferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50: 0.900nMAssay Description:Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed