BDBM50164450 (S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione::CHEMBL370758

SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12

InChI Key InChIKey=CTZWGZSINBFHFD-UHFFFAOYSA-N

Data  8 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50164450   

Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataEC50:  150nMAssay Description:Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi:  4.10nMAssay Description:In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi:  8.90nMAssay Description:In vitro inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi:  101nMAssay Description:In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi:  192nMAssay Description:In vitro inhibition of [3H]-raclopride binding to Dopamine receptor D2 in rat striatum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi:  976nMAssay Description:In vitro inhibition of [3H]paroxetine binding to 5-hydroxytryptamine transporter in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibition of [3H]GR-113808 binding to 5-hydroxytryptamine 4 receptor of rat striatum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed
LigandPNGBDBM50164450((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article
PubMed