BDBM50163371 CHEMBL3794155

SMILES O=C(Cc1ccc(nc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1

InChI Key InChIKey=DSTPQJIKZPOBFY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50163371   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50163371(CHEMBL3794155)
Affinity DataIC50: 29nMAssay Description:Inhibition of human ROMK expressed in CHO cells by whole-cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50163371(CHEMBL3794155)
Affinity DataIC50: 86nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50163371(CHEMBL3794155)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human ERG by electrophysiology analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50163371(CHEMBL3794155)
Affinity DataIC50: 9.30E+3nMAssay Description:Displacement of [35S]-MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed