BDBM50162978 4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-[1,3,5]triazin-2-ol::CHEMBL176078

SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1

InChI Key InChIKey=CUTRRQNUXLUQCJ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50162978   

TargetInsulin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of beta IRK tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of PDGF-R2 tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Insulin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of c-fms tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 49nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Mouse)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed