BDBM50162816 CHEMBL180570::Medronic acid::Methylene diphsphonate::Phosphonomethyl-phosphonic acid::methylenediphosphonic acid

SMILES C(P(=O)(O)O)P(=O)(O)O

InChI Key InChIKey=MBKDYNNUVRNNRF-UHFFFAOYSA-N

Data  9 KI  3 IC50

PDB links: 6 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50162816   

TargetCarbonic anhydrase 2(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataIC50: 1.25E+6nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 pretreated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataIC50: 8.60E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 pretreated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of human recombinant MMP-2 pretreated for 30 mins measured 2 to 4 hrs after Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetType IV secretion-like conjugative transfer relaxase protein TraI(Escherichia coli (strain SMS-3-5 / SECEC))
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  3nMAssay Description:Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetFe(3+)-Zn(2+) purple acid phosphatase(Kidney bean)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition of red kidney beans purple acid phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  1.25E+6nMAssay Description:Binding affinity towards human cytosolic carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  5.34E+6nMAssay Description:Binding affinity towards human membrane associated carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  7.30E+5nMAssay Description:Binding affinity towards recombinant human mitochondrial carbonic anhydrase VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  8.60E+5nMAssay Description:Binding affinity owards recombinant human transmembrane carbonic anhydrase IXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrnithine transcarbamylase, mitochondrial(Human)
Universit£Tstrasse 16

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi: >2.00E+7nMpH: 7.0Assay Description:Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2012
Entry Details Article
PubMed
TargetOrnithine transcarbamylase, mitochondrial(Human)
Universit£Tstrasse 16

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi: >2.00E+7nMpH: 6.0Assay Description:Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM maleate, 0.5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2012
Entry Details Article
PubMed
TargetOrnithine transcarbamylase, mitochondrial(Human)
Universit£Tstrasse 16

Curated by ChEMBL
LigandPNGBDBM50162816(Medronic acid | methylenediphosphonic acid | Methy...)
Affinity DataKi:  9.00E+6nMpH: 8.0Assay Description:Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2012
Entry Details Article
PubMed