BDBM50162147 1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea::CHEMBL178455

SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC

InChI Key InChIKey=LFKQSJNCVRGFCC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50162147   

TargetVascular endothelial growth factor receptor 2(Human)
Meiji Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Meiji Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Meiji Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 in cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of epidermal growth factor receptor in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 40nMAssay Description:Inhibition of proto-oncogene tyrosine-protein kinase kit in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mitogen activated protein kinase in cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of epidermal growth factor receptor in cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 170nMAssay Description:Inhibition of fibroblast growth factor receptor 2 in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hepatocyte growth factor receptor in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 67nMAssay Description:Inhibition of platelet-derived growth factor receptor alpha in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCdk-related protein kinase 6(Plasmodium falciparum)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 14nMAssay Description:Inhibition of plasmodium falciparum PK6 incubated for 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 360nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed