BDBM50162083 (5-Methyl-1H-pyrazol-3-yl)-(2-phenyl-quinazolin-4-yl)-amine::(5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine::CHEMBL359482::N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-amine::N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE

SMILES Cc1cc(Nc2nc(nc3ccccc23)-c2ccccc2)[nH]n1

InChI Key InChIKey=JYCUVOXSZBECAY-UHFFFAOYSA-N

Data  7 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50162083   

TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataIC50: 858nMAssay Description:Inhibition of Aurora B (unknown origin) using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of Aurora A (unknown origin) using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  22nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  22nMAssay Description:Inhibition of Gsk3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  24nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  58nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  58nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  81nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162083(N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-...)
Affinity DataKi:  81nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed