BDBM50161834 CHEMBL3794175

SMILES COc1ccc(cc1OC)C(C)(C)c1cnc(SCc2c(F)cccc2Cl)n1-c1ccc(F)cc1

InChI Key InChIKey=NGCFQZZMKMQQAL-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50161834   

TargetG-protein coupled bile acid receptor 1(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50161834(CHEMBL3794175)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50161834(CHEMBL3794175)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50161834(CHEMBL3794175)
Affinity DataEC50:  17nMAssay Description:Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50161834(CHEMBL3794175)
Affinity DataEC50: <100nMAssay Description:Agonist activity at TGR5 in human HEK293 cells incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed