BDBM50161828 CHEMBL3793310

SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1

InChI Key InChIKey=PRMXPZIOPNPPCX-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50161828   

TargetPolyamine deacetylase HDAC10(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of human HDAC10 using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human HDAC9 using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human recombinant HDAC2 using Fluor de Lys Green as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using BOC-Ac-Lys-AMC as substrate incubated for 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of human recombinant C-terminal His-tagged, N-terminal GST-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using RHK-K(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 580nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/human recombinant N-terminal GST-tagged NCOR2 (395 to 489...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50161828(CHEMBL3793310)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed