BDBM50161745 CHEMBL179036::{3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1,2,3,4-tetrahydro-carbazol-9-yl}-acetic acid

SMILES CN([C@@H]1CCc2c(c3ccccc3n2CC(=O)O)C1)S(=O)(=O)c4ccc(cc4)F

InChI Key InChIKey=CANCTKXGRVNXFP-UHFFFAOYSA-N

Data  11 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50161745   

TargetThromboxane A2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta-arrestin translocation at Thromboxane A2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThromboxane A2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta-arrestin translocation at human Thromboxane A2 receptor in BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of CRTH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGD2-induced inositol phosphate formation at human Prostaglandin D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of CRTH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin D2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  653nMAssay Description:Binding affinity to prostanoid DP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  1.12E+3nMAssay Description:Binding affinity to prostanoid DP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  1.39E+3nMAssay Description:Binding affinity to thromboxane receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi:  6.85E+3nMAssay Description:Binding affinity to thromboxane receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]SQ-29,548 binding to human Thromboxane A2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50161745({3-[((R)-4-Fluoro-benzenesulfonyl)-methyl-amino]-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of TP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed