BDBM50161467 CHEMBL3785560

SMILES Oc1ccc(Cl)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12

InChI Key InChIKey=HBTHUUQDNVQVHD-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50161467   

TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161467(CHEMBL3785560)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50161467(CHEMBL3785560)
Affinity DataIC50: 1.73E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161467(CHEMBL3785560)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161467(CHEMBL3785560)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2017
Entry Details Article
PubMed