BDBM50160900 CHEMBL181617::N*4*-(3-Bromo-phenyl)-N*6*-(2-chloro-ethyl)-quinazoline-4,6-diamine

SMILES ClCCNc1ccc2ncnc(Nc3cccc(Br)c3)c2c1

InChI Key InChIKey=NPLZGCKBBUBACR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50160900   

TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50160900(N*4*-(3-Bromo-phenyl)-N*6*-(2-chloro-ethyl)-quinaz...)
Affinity DataIC50: 10nMAssay Description:Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50160900(N*4*-(3-Bromo-phenyl)-N*6*-(2-chloro-ethyl)-quinaz...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 8 mins in presence of ATP by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed