BDBM50160879 CHEMBL3793392::US9505736, (1S,2S,3S)-1-Fluoro-2-(4-(5- fluoropyrimidin-2-yl)phenyl)-N-hydroxy-3- phenylcyclopropanecarboxamide

SMILES ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1ncc(F)cn1)c1ccccc1

InChI Key InChIKey=MREATSZIGJDNKB-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50160879   

TargetHistone deacetylase 4 [648-729,745-1057](Human)
Chdi Foundation

US Patent
LigandPNGBDBM50160879(US9505736, (1S,2S,3S)-1-Fluoro-2-(4-(5- fluoropyri...)
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description:The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160879(US9505736, (1S,2S,3S)-1-Fluoro-2-(4-(5- fluoropyri...)
Affinity DataKd:  20nMAssay Description:Binding affinity to HDAC4 catalytic domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2017
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160879(US9505736, (1S,2S,3S)-1-Fluoro-2-(4-(5- fluoropyri...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed