BDBM50159488 CHEMBL3787197

SMILES CC(C)OC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1

InChI Key InChIKey=NYHLRBMDXQBOIB-UHFFFAOYSA-N

Data  12 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50159488   

TargetCytochrome P450 3A4(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in insect cell microsomes using dibenzylfluorescein substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using DBF as substrate preincubated for 5 mins followed by substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NECA from human A3 receptor expressed in human HeLa cell membranes incubated for 180 mins by radioligand binding competition assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]NECA from human A3 receptor expressed in human HeLa cell membranes incubated for 180 mins by radioligand binding competition assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  3.5nMAssay Description:Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane assessed as inhibition constant incubated for 30 mins by competitive bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]DPCPX from human recombinant A1 receptor expressed in CHOA1 cell membranes incubated for 60 mins by radioligand binding competiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]DPCPX from human recombinant A1 receptor expressed in CHOA1 cell membranes incubated for 60 mins by radioligand binding competiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]ZM241385 from human recombinant A2A receptor expressed in human HeLa cell membranes incubated for 30 mins by radioligand binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50159488(CHEMBL3787197)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]ZM241385 from human recombinant A2A receptor expressed in human HeLa cell membranes incubated for 30 mins by radioligand binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed