BDBM50158618 CHEMBL3787341::US9850257, Example 11

SMILES Cc1noc(C)c1-c1ccc2c3c1OCC(c1cccnc1)n3n(C)c2=O

InChI Key InChIKey=JIWZXZCQZJYFQM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158618   

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158618(CHEMBL3787341 | US9850257, Example 11)
Affinity DataIC50: 200nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 from human his-tagged BRD4 bromodomain1 after 75 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandPNGBDBM50158618(CHEMBL3787341 | US9850257, Example 11)
Affinity DataIC50: 200nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM50158618(CHEMBL3787341 | US9850257, Example 11)
Affinity DataIC50: 200nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent