BDBM50158422 CHEMBL388340::N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo-[2,3-d]pyrimidin-5-yl)thio]-2'fluorobenzoyl]L-glutamic acid

SMILES Cc1[nH]c2nc(N)[nH]c(=O)c2c1Sc1ccc(C(=O)N[C@@H](CCC(O)=O)C(O)=O)c(F)c1

InChI Key InChIKey=LTCOTSRHIWKZTK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158422   

TargetThymidylate synthase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50158422(N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrro...)
Affinity DataIC50: 720nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50158422(N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrro...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50158422(N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrro...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed