BDBM50158419 CHEMBL3734798

SMILES C[C@@H](Oc1cc(cnc1N)-c1ccn(n1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl

InChI Key InChIKey=CCASRZWPCOLUMW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50158419   

TargetHepatocyte growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50158419(CHEMBL3734798)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50158419(CHEMBL3734798)
Affinity DataIC50: 261nMAssay Description:Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50158419(CHEMBL3734798)
Affinity DataIC50: 151nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50158419(CHEMBL3734798)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of Tel fused InsR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50158419(CHEMBL3734798)
Affinity DataIC50: 7nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50158419(CHEMBL3734798)
Affinity DataIC50: 64nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed