BDBM50158094 CHEMBL3780926

SMILES c1ccc(cc1)CC2CCN(CC2)CCN

InChI Key InChIKey=PCNDXYHWLSHXMV-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50158094   

TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of FLAG-tagged human PRMT6 expressed in HEK293 cells assessed as reduction in H3R2 global methylation incubated for 20 hrs by Western blot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 1 [11-371](Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human PRMT1 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataKd:  970nMAssay Description:Binding affinity to Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 230nMAssay Description:Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PRMT4 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human PRMT3 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human PRMT8 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CARM1 (unknown origin) using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed