BDBM50157562 1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one::3,3',4,4'-tetrahydroxychalcone::CHEMBL225618::US9085549, 94

SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O

InChI Key InChIKey=DOWSJIIZLUFMFM-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50157562   

TargetMicrotubule-associated protein tau(Human)
Proteotech

US Patent
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50: 2.14E+4nMAssay Description:The Thio S fluorometry assay as a primary screening method to identify tau protein aggregation inhibitors from our small molecule library. Aggregated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent

TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
Northern Kentucky University

Curated by ChEMBL
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetArginase-1(Bovine)
Universite de Franche-Comte

Curated by ChEMBL
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50: 9.11E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Proteotech

US Patent
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataKi:  1.10E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent