BDBM50157547 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4-one::7,8,3',4'-tetrahydroxyflavone::CHEMBL222541

SMILES c1cc(c(cc1C2=CC(=O)c3ccc(c(c3O2)O)O)O)O

InChI Key InChIKey=ARYCMKPCDNHQCL-UHFFFAOYSA-N

Data  8 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50157547   

TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Institute For Theoretical Medicine

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 70nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 200nMAssay Description:Inhibition of telomerase in human HEK293 cells by flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 250nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 230nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 740nMAssay Description:Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50157547(7,8,3',4'-tetrahydroxyflavone | 2-(3,4-dihydroxyph...)
Affinity DataIC50: 204nMAssay Description:Inhibition of human recombinant BRD4-BD2 expressed in Escherichia coli using C-Terminal-biotinylated histone H4 peptide as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed