BDBM50156509 4-((1S,6R,7S)-8-Benzoyl-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl)-2-trifluoromethyl-benzonitrile::CHEMBL189600

SMILES Oc1c2[C@@H]3C[C@@H](CN3C(=O)c3ccccc3)n2c(=O)n1-c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=WDSFCSOIFMEQHG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50156509   

TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156509(4-((1S,6R,7S)-8-Benzoyl-3,5-dioxo-2,4,8-triaza-tri...)
Affinity DataIC50: 300nMAssay Description:In vitro antagonistic activity against androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156509(4-((1S,6R,7S)-8-Benzoyl-3,5-dioxo-2,4,8-triaza-tri...)
Affinity DataIC50: 2.60E+3nMAssay Description:In vitro antagonistic activity against mutant androgen receptor of LNCap cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156509(4-((1S,6R,7S)-8-Benzoyl-3,5-dioxo-2,4,8-triaza-tri...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]DHT from androgen receptor of human MDA-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed