BDBM50154993 2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetrazol-5-yl]-pyridine::CHEMBL359575

SMILES Cc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1

InChI Key InChIKey=XESADNWQZMVYOQ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154993   

TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154993(2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...)
Affinity DataIC50: 120nMAssay Description:Antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154993(2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...)
Affinity DataIC50: 120nMAssay Description:In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154993(2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed