BDBM50154956 CHEMBL3775317

SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@@H](O)C2)cc1

InChI Key InChIKey=MUKGYZFIZLFCGL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154956   

TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50154956(CHEMBL3775317)
Affinity DataIC50: 2nMAssay Description:Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50154956(CHEMBL3775317)
Affinity DataIC50: 42nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50154956(CHEMBL3775317)
Affinity DataIC50: 6nMAssay Description:Binding affinity to CDK8/Cyclin C (unknown origin) by reporter displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed