BDBM50154442 2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid::CHEMBL188448

SMILES c1cc(ccc1C2=NC(=C(C(=O)N2)O)C(=O)O)Cl

InChI Key InChIKey=XNDKQQKHTBDWNQ-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50154442   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory concentration required to inhibit HIV-integrase is determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibitory concentration required to inhibit HIV-RT is determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase I(Escherichia coli (strain K12))
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of HCV NS5B Cdelta55 RNA dependent RNA polymerase expressed in Escherichia coli assessed as reduction in [3H]UTP incorporation using poly(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50154442(2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase p66/p51 polymerase using PPT57 DNA/Cy5-labeled PPT24 as template/primer preincubated for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed