BDBM50153707 CHEMBL3775824

SMILES CC(C)CN1CCc2cc(ccc2[C@H]1c3ccc(cc3)/C=C/C(=O)O)O

InChI Key InChIKey=PRJBEVDNTURUGU-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153707   

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153707(CHEMBL3775824)
Affinity DataIC50: 4.40nMAssay Description:Downregulation of ERalpha in human MCF7 cells incubated for 18 to 22 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153707(CHEMBL3775824)
Affinity DataIC50: 26nMAssay Description:Displacement of fluormone ES2 from GST-tagged recombinant human ERalpha LBD after 1 hr by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153707(CHEMBL3775824)
Affinity DataIC50: 25nMAssay Description:Binding affinity to recombinant human GST-tagged ERalpha LBD expressed in baculovirus-infected insect cells by lantha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153707(CHEMBL3775824)
Affinity DataIC50: 4nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 18 to 24 hrs by in multiplexed cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed