BDBM50153596 CHEMBL3775765

SMILES CCn1c(SCC(=O)Nc2cccc3ccccc23)nnc1C1Cc2ccccc2C1

InChI Key InChIKey=FZEMCLIWPIMPQX-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153596   

TargetCytochrome P450 3A4(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153596(CHEMBL3775765)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153596(CHEMBL3775765)
Affinity DataEC50:  850nMAssay Description:Inhibition of human GST-tagged RORgamma ligand binding domain (253 to 518 residues) expressed in sf9 cells using biotin-EEPSLLKKLLLAPA by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153596(CHEMBL3775765)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of human RORgamma ligand binding domain (Serine 253 to Lysine 518 residues) expressed in CHOK1 cells incubated for 2 days by Gal4 lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153596(CHEMBL3775765)
Affinity DataEC50:  700nMAssay Description:Inhibition of mouse RORgamma ligand binding domain (Isoleucine 251 to Lysine 516) expressed in CHOK1 cells incubated for 2 days by Gal4 luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed