BDBM50153589 CHEMBL3775312::US10053456, 95::US10414761, Example 95::US10968213, Example 95::US9487511, 95::US9718814, 95::US9920047, 95

SMILES Cc1nnc(NC(=O)c2cc([C@@H]3C[C@H]3NCC3CC3)c(C)s2)s1

InChI Key InChIKey=LTGSMINAMWCXSG-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153589   

TargetLysine-specific histone demethylase 1A(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50153589BDBM50153589(US9487511, 95 | CHEMBL3775312 | US10053456, 95 | U...)
Affinity DataIC50: 180nMpH: 8.0 T: 2°CAssay Description:A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50153589BDBM50153589(US9487511, 95 | CHEMBL3775312 | US10053456, 95 | U...)
Affinity DataIC50: 180nMAssay Description:Inhibition of GST-tagged human LSD1 (172 to 833 residues) expressed in Escherichia coli C43(DE3) pLysS using biotinylated histone H3 mono methylated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50153589BDBM50153589(US9487511, 95 | CHEMBL3775312 | US10053456, 95 | U...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50153589BDBM50153589(US9487511, 95 | CHEMBL3775312 | US10053456, 95 | U...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent