BDBM50153549 3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxolan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide::CHEMBL363930

SMILES CCN(CC)c1ccc(NC(=O)c2c(CCC3OCCO3)onc2-c2c(Cl)cccc2Cl)cc1

InChI Key InChIKey=GTVREPKLJZRLEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50153549   

TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153549(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxolan-2-yl-et...)
Affinity DataIC50: 25nMAssay Description:Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153549(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxolan-2-yl-et...)
Affinity DataIC50: 56nMAssay Description:Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed