BDBM50153528 5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-cyclohexyl)-amide::CHEMBL365294

SMILES CCN(CC)[C@H]1CC[C@@H](CC1)NC(=O)c1c(CCc2ccc3OCOc3c2)onc1-c1c(Cl)cccc1Cl

InChI Key InChIKey=ZMXSCCKIRGCWFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153528   

TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153528(5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against mouse Growth hormone secretagogue receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153528(5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against rat Growth hormone secretagogue receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153528(5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-...)
Affinity DataIC50: 54nMAssay Description:Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153528(5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-...)
Affinity DataIC50: 32nMAssay Description:Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed