BDBM50153501 (4-Fluoro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-methanol::CHEMBL184109

SMILES C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1ccc(F)cc1)-c1ccc(F)cc1

InChI Key InChIKey=LMWKGVHGBOZNCF-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153501   

TargetGlucocorticoid receptor(Rat)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50153501((4-Fluoro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...)
Affinity DataEC50:  8nMAssay Description:Effective concentration against MMTV in transactivation assay in U2OS cells expressing rat GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50153501((4-Fluoro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...)
Affinity DataEC50:  3nMAssay Description:Repression of NF-kappaB-luciferase reporter activity in TPA stimulated U2OS cells expressing rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50153501((4-Fluoro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...)
Affinity DataEC50:  1.70nMAssay Description:Repression of AP1-luciferase reporter activity in TPA-stimulated U2OS cells expressing rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50153501((4-Fluoro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed