BDBM50153254 5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid::5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid::5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid::CHEMBL366051

SMILES Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccs1

InChI Key InChIKey=CWHZCSASLVDDDM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50153254   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50153254(5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dih...)
Affinity DataIC50: 4.20E+3nMAssay Description:inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50153254(5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dih...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50153254(5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dih...)
Affinity DataIC50: 460nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50153254(5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dih...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFlap endonuclease 1(Human)
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50153254(5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dih...)
Affinity DataIC50: 8.89E+4nMAssay Description:Inhibition of FEN1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2016
Entry Details Article
PubMed
TargetDeoxyribonuclease-1(Human)
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50153254(5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dih...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DNAse1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2016
Entry Details Article
PubMed