BDBM50153092 CHEMBL3775894

SMILES c1cnc(c2c1C(=O)NC=N2)n3cc(cn3)CCN4CCC(CC4)c5cc(cc(c5)Cl)Cl

InChI Key InChIKey=RLRGPZGIQMEBLC-UHFFFAOYSA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50153092   

TargetLysine-specific demethylase 3A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 51nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 80nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of KDM2A (unknown origin) using biotin-H3K36me2 (28 to 48 residues) as substrate preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 14nMAssay Description:Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153092(CHEMBL3775894)
Affinity DataIC50: 14nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)