BDBM50153040 3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazole::CHEMBL363228

SMILES Cc1c(c(no1)c2ccc(o2)Cl)c3ccccc3

InChI Key InChIKey=IPAVFMUBTIUYBW-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50153040   

TargetProstaglandin G/H synthase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 500nMAssay Description:Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Sheep)
Thomas Jefferson University

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant ovine COX2 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of ovine COX1 by peroxidase activity-based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX-2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 500nMAssay Description:Inhibition of COX-1 in human whole blood assessed as inhibition of serum TXB2 level after 1 hr by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of COX-1 (unknown origin) in platelet rich plasma assessed as inhibition of collagen-induced TXB2 formation incubated for 5 mins prior to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of COX-1 (unknown origin) in platelet rich plasma assessed as inhibition of arachidonic acid-induced TXB2 formation incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human platelet COX1 by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human monocyte COX2 by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed