BDBM50151907 3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile::CHEMBL365499

SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1

InChI Key InChIKey=OGIBYDWBTRKAOL-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50151907   

TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataIC50: 73nMAssay Description:Antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration towards human glutamate receptor 5 in calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataIC50: 73nMAssay Description:In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataKi:  102nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataKi:  186nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from glutamate 5 receptor of rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151907(3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...)
Affinity DataKi:  190nMAssay Description:Ability to displace [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed