BDBM50151845 CHEMBL3775504

SMILES CN(C)C(=O)c1ccc(Oc2nc(nc(n2)-c2cccc3[nH]ncc23)N2CCOCC2)cc1

InChI Key InChIKey=HOLZLKJUQNXYRK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50151845   

LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed