BDBM50151644 CHEMBL359890::ethyl 5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-5-yloxymethyl]-2-furoate

SMILES CCOC(=O)c1ccc(COc2ccc(Cl)c3NC(=O)NC4(CCCCC4)c23)o1

InChI Key InChIKey=LRJDXDRKLRBINJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151644   

LigandPNGBDBM50151644(ethyl 5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human PDE5 partially purified from MCF-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151644(ethyl 5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''...)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151644(ethyl 5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''...)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151644(ethyl 5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151644(ethyl 5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed