BDBM50151637 8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-2''-one::CHEMBL185108

SMILES CN(C)CCCOc1ccc(Cl)c2NC(=O)NC3(CCCCC3)c12

InChI Key InChIKey=RYMSZFRCYIQMRX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151637   

LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human PDE5 partially purified from MCF-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed