BDBM50151462 (1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid::CHEMBL363940::US10689327, Compound (II)-9

SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC1CCCC1)[C@]2(F)C(O)=O)C(O)=O

InChI Key InChIKey=OQCWNVPJUJCZIF-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50151462   

TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM50151462((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Affinity DataIC50: 62.2nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 3(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM50151462((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Affinity DataIC50: 97.6nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM50151462((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Affinity DataKi:  8.57nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed