BDBM50151355 5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-ylamine::CHEMBL181958

SMILES Nc1nc(c(s1)-c1ccnc2ncccc12)-c1ccccn1

InChI Key InChIKey=PQGWZYBFJQPWRT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50151355   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151355(5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-...)
Affinity DataIC50: 7.94E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (3.221-19.588)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151355(5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed