BDBM50151346 5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine::5-[1,5]Naphthyridin-2-yl-4-pyridin-2-yl-thiazol-2-ylamine::CHEMBL181361

SMILES Nc1nc(c(s1)-c1ccc2ncccc2n1)-c1ccccn1

InChI Key InChIKey=NQQBKOGAKSBCSI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50151346   

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50: 40nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.038-0.042)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50: 120nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed