BDBM50151183 5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine::CHEMBL188897

SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN(Cc2ccccc2)CC1

InChI Key InChIKey=KPTVFLZETSRCFF-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151183   

TargetAdenosine receptor A2b(Human)
Universita Di Trieste

Curated by ChEMBL
LigandPNGBDBM50151183(5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]tr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Universita Di Trieste

Curated by ChEMBL
LigandPNGBDBM50151183(5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]tr...)
Affinity DataKi:  20.6nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50151183(5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]tr...)
Affinity DataKi:  140nMAssay Description:Inhibition of [3H]ZM-241,385 binding to rat brain adenosine A2a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50151183(5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]tr...)
Affinity DataKi: >500nMAssay Description:Inhibition of [3H]DPCPX binding to rat cerebral cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Universita Di Trieste

Curated by ChEMBL
LigandPNGBDBM50151183(5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]tr...)
Affinity DataKi:  978nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed