BDBM50150702 3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl]-pyrrole-2,5-dione::CHEMBL362588

SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23

InChI Key InChIKey=HHSIUHRARDLCPM-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50150702   

TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human Cyclin-dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human PDK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human MLK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Protein kinase A betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human Protein kinase C beta 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human TGF-beta type II receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human Cyclin-dependent kinase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 1.60nMAssay Description:Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed