BDBM50150141 2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole::CHEMBL127257

SMILES Cc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1

InChI Key InChIKey=SAQMCVDGOIRQTC-UHFFFAOYSA-N

Data  19 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50150141   

TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory concentration tested on human D4.4 receptor in HEK293 cells using FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity tested on HEK293 cells co-transfected with human D4.4 receptor using [3H]spiperone as a radioligand in FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-spiperone from human D4 receptor expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  370nMAssay Description:Inhibition of serotonin 5-HT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  1.37E+3nMAssay Description:Inhibition of serotonin 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi:  1.91E+3nMAssay Description:Inhibition of alpha2C adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of serotonin 5-HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of serotonin 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of serotonin 5-HT7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of alpha2A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of serotonin 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of sigma2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of human dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [3H]-spiperone from human D2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [3H]-spiperone from human D3 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of human dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50150141(2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of human dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed