BDBM50150090 CHEMBL125902::[3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin-5-yloxy)-ethyl]-amine

SMILES Fc1ccc2[nH]cc(CCCNCCOc3cccc4nccnc34)c2c1

InChI Key InChIKey=VWAVMVBNSJOHSA-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50150090   

TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150090([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin...)
Affinity DataIC50: 20nMAssay Description:Inhibition concentration against [3H]5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150090([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin...)
Affinity DataEC50:  13.7nMAssay Description:Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150090([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin...)
Affinity DataEC50:  46nMAssay Description:Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150090([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]paroxetineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150090([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed