BDBM50150087 CHEMBL435612::[2-(5-Fluoro-2,3-dihydro-benzofuran-7-yloxy)-ethyl]-[2-(5-fluoro-1H-indol-3-yl)-ethyl]-amine

SMILES Fc1ccc2[nH]cc(CCNCCOc3cc(F)cc4CCOc34)c2c1

InChI Key InChIKey=VRHDCZABKKGHEU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50150087   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150087([2-(5-Fluoro-2,3-dihydro-benzofuran-7-yloxy)-ethyl...)
Affinity DataIC50: 138nMAssay Description:Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150087([2-(5-Fluoro-2,3-dihydro-benzofuran-7-yloxy)-ethyl...)
Affinity DataIC50: 254nMAssay Description:Inhibition concentration against [3H]5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150087([2-(5-Fluoro-2,3-dihydro-benzofuran-7-yloxy)-ethyl...)
Affinity DataKi:  10.5nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]paroxetineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150087([2-(5-Fluoro-2,3-dihydro-benzofuran-7-yloxy)-ethyl...)
Affinity DataKi:  35.1nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed