BDBM50149925 CHEMBL3770740

SMILES Oc1cc(Oc2nc3cnccc3c(=O)[nH]2)ccc1Cl

InChI Key InChIKey=OZMKCTFOIBLWOO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50149925   

TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 398nMAssay Description:Inhibition of N-terminal his-tagged human KDM4C expressed in Escherichia coli BL21(DE3) using trimethylated peptide substrate by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM5C catalytic domain (1 -764 aa) (unknown origin) expressed in Sf9 cells using H3K4Me3 peptide as substrate by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 126nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 398nMAssay Description:Inhibition of KDM4A (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full-length EGLN3 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human KDM5C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 316nMAssay Description:Inhibition of KDM4D (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 398nMAssay Description:Inhibition of N-terminal his-tagged human KDM4C expressed in Escherichia coli BL21(DE3) using trimethylated peptide substrate by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 6B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KDM6B (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149925(CHEMBL3770740)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of N-terminal his-tagged full-length human KDM4C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed