BDBM50149895 CHEMBL3770000

SMILES CCN(C1CCOCC1)c1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key InChIKey=FADJTYGNEWCCFM-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50149895   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL

LigandBDBM50149895(CHEMBL3770000)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/24/2017
Entry Details Article
Copy Entry DOIPubMed
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TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL

LigandBDBM50149895(CHEMBL3770000)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL