BDBM501491 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(1-methyl-1,2,4-triazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11026923, Example 121::US11026923, Example 122

SMILES CCOc1ncccc1-c1cc(NCC(=N)\N=C/N)c(NC(C)CC)c(n1)C(C)=N

InChI Key InChIKey=SBJLYMCDQIHVMN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 501491   

LigandPNGBDBM501491(US11026923, Example 121 | US11026923, Example 122 ...)
Affinity DataIC50: 0.150nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501491(US11026923, Example 121 | US11026923, Example 122 ...)
Affinity DataIC50: 0.470nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501491(US11026923, Example 121 | US11026923, Example 122 ...)
Affinity DataIC50: 2.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501491(US11026923, Example 121 | US11026923, Example 122 ...)
Affinity DataIC50: 3.5nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501491(US11026923, Example 121 | US11026923, Example 122 ...)
Affinity DataIC50: 4nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501491(US11026923, Example 121 | US11026923, Example 122 ...)
Affinity DataIC50: 10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent