BDBM50148864 CHEMBL3771122::US10533010, Example I-74::US11208415, Example I-74

SMILES Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)NCc1cc(C(O)=O)n(C)c1

InChI Key InChIKey=ASMOXSKXETVZOR-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50148864   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant Mcl-1 (residues 172-327) (unknown origin) using FITC-AHx-GQVGRQLAIIGDDINR-NH2 as substrate after 90 mins by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2017
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi:  24nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi:  24nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi: <50nMAssay Description:Inhibition of recombinant Mcl-1 (residues 172-327) (unknown origin) using FITC-AHx-EARIAQELRRIGDEFNETYTR-NH2 as substrate after 90 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2017
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi:  3.54E+3nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi:  3.54E+3nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi: >1.00E+5nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50148864(CHEMBL3771122 | US10533010, Example I-74 | US11208...)
Affinity DataKi: >1.00E+5nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent