BDBM50148735 2-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-yl}-ethoxy)-ethanol::CHEMBL326706

SMILES OCCOCCN1C2CCC1CC(C2)OC(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=SPARNWYFZQKTHR-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50148735   

TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148735(2-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicy...)
Affinity DataKi:  42.6nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50148735(2-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicy...)
Affinity DataKi:  49.0nMAssay Description:Ability of compound to inhibit dopamine uptake of receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148735(2-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicy...)
Affinity DataKi:  336nMAssay Description:Binding affinity at muscarinic M1 receptor in rat brain by [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148735(2-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicy...)
Affinity DataKi:  3.65E+3nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148735(2-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicy...)
Affinity DataKi:  1.43E+4nMAssay Description:Binding affinity at serotonin transporter in rat brain by [3H]-citalopram displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed